Beilstein J. Org. Chem.2014,10, 2065–2070, doi:10.3762/bjoc.10.214
the synthesis of α-aminoamidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom
economy, wide substrate scope and high yields.
Keywords: α-aminoamidines; iodine; isocyanide; multicomponent reaction; Ugi reaction; Introduction
Amidines are a class of organic compounds exhibiting a variety of biological activity that makes them potential candidates for drug development and discovery
], ZnO nanoparticles [18] and BF3·OEt2 [19] were reported with varying degrees of success. All these reported methods for the preparation of α-aminoamidines have their own limitations such as long reaction times, high catalyst loading and use of expensive and hazardous metal catalysts. Therefore, the
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Graphical Abstract
Figure 1:
Synthesis of diamides, α-amino amides [13,14] and α-amino amidines [15-19] through Ugi and related MCRs.